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Tesofensine may cause more sleep or mood-related side effects

Normal mitochondrial membrane potential is required for oxidative phosphorylation and the generation of ATP

10.1016/j.pcl.2018.12.009 42 KimY.DavidsonJ

Replacement of Tyr110 in recombinant Y110A decreased both k cat app and 1/ values for the disulfide substrate and GSH in the GSSCys and HEDS assay (Supplementary Figs 18 and 19)